Plasma p-Tau217 Flags Alzheimer’s Pathology in Other Disorders
The marker detected plaques and tangles with 90 percent accuracy in almost 200 autopsy-confirmed frontotemporal dementia cases.
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Does COVID-19 Push People Toward Alzheimer’s? New Data Say Yes.
Plasma Aβ42/40 ratios drop in people soon after COVID-19 infection even for mild cases. Does this mean they are at higher risk for dementia?
Studying Diverse Populations May Require New Biomarkers
Amyloid and tau accumulation patterns differ in black, white, and Hispanic people.
When Tau Wanders Off, Subcortical Axon Firing Goes Mum
At HAI, scientists report that tangle accumulation in tracts from the locus coeruleus keeps neural systems from communicating with one another when neurons die.
Human Amyloid Imaging 2025
At Human Amyloid Imaging Conference, Plasma Tau Was the Star When Tau Wanders Off, Subcortical Axon Firing Goes Mum Studying Diverse Populations May Require New Biomarkers After 14 years in Miami, HAI is on the move again. This January conference started
At Human Amyloid Imaging Conference, Plasma Tau Was the Star
In Puerto Rico, scientists agreed that jointly measuring multiple plasma tau markers could be a powerful readout of tau pathology in a person’s brain.
New Biomarkers Catch Tau Before It Tangles
Scientists characterize early stage tau aggregates and develop a CSF test to track them.
Does CSF Aβ Reflect Protofibril Concentration, Rather Than Plaques?
In mice, this marker correlated better with amyloid protofibrils in the brain than with plaques. So did CSF markers of neurodegeneration, highlighting the toxicity of protofibrils.
Expanded Repeat Sequences Raise a Person’s Risk for Alzheimer’s
Two studies tie repeated stretches of DNA to increased odds for AD. One encodes poly-GR peptides that aggregate.
Proteomics Lays Groundwork for FTD Biomarkers
Surveys of CSF proteins from the GENFI and ALLFTD genetic cohorts flag altered biological processes and point toward FTD fluid markers.
Expunging Microglial Lipid Droplets Boosts Phagocytosis
An endoplasmic reticulum protein helps lipids bud from this organelle. Knocking out the protein in microglia curtailed lipid droplets, and enhanced amyloid clearance.
Single-Molecule Imaging Spies Protein Aggregates in Synapses
A new super-resolution microscopy technique sheds light on synaptic dysfunction.
From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check
Mice have a small pool of such Tregs. Removing them hobbles the hippocampus, beckons immune invasion, revs glia, and quashes neurogenesis.
ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
In AD mouse models, replacing ApoE3 with ApoE3Ch preserves memory.
Leqembi Maintenance Dosing Approved in the U.S.
The nod will allow people who have completed 18 months of biweekly IV dosing to transition to monthly IVs. An application for subcutaneous dosing is pending.
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