Stanley Rapoport, M.D.

National Institute on Aging

Contact Information

Stanley Rapoport, M.D.
Bethesda, United States

Professional Information

Chief, Brain Physiology Metabolism Section
National Institute on Aging

Education

A.B. Princeton University M.D. Harvard Medical School Medicine Internship, Bellevue Hospital, NY Post-doctoral training: -- Laboratory of Neurosciences, NIMH -- Dept Physiology, University Uppsala, Sweden

Bio

I contributed to our understanding of the blood-brain barrier and developed an osmotic method to enhancing drug entry into the brain for treating brain tumors. I used positron emission tomography (PET) to characterize changes in brain blood flow and glucose metabolism in human aging and Alzheimer disease. I also developed methods to quantify and image brain fatty acid metabolism in unanesthetized rodents and humans. With these methods, I elucidate roles of the polyunsaturated arachidonic and docosahexaenoic acids in neurotransmission and neuroinflammation. Recent findings that mood stabilizers selectively downregulate rat brain arachidonic acid metabolism suggest a mechanism for their efficacy in bipolar disorder.