Schmidt FM, Mergl R, Stach B, Jahn I, Gertz HJ, Schönknecht P. Elevated levels of cerebrospinal fluid neuron-specific enolase (NSE) in Alzheimer's disease. Neurosci Lett. 2014 Jun 6;570:81-5. Epub 2014 Apr 16 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : NSE (CSF)
- CTRL vs AD : NSE (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| NSE (CSF) |
AD (32) |
20.45 ± 7.21 ng/mL |
Electrochemiluminescence; Other/Not Specified; Roche Diagnostics |
|
| NSE (CSF) |
CTRL- CNC (32) |
6.43 ± 4.1 ng/mL |
Electrochemiluminescence; Elecsys; Roche Diagnostics |
|
| tau-p181 (CSF) |
AD (32) |
79.19 ± 36.2 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-p181 (CSF) |
CTRL- CNC (32) |
33.93 ± 13.79 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
AD (32) |
470.53 ± 260.44 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
CTRL- CNC (32) |
137.1 ± 53.33 pg/mL |
ELISA; Innotest; Innogenetics |
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