NCT01690195
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Research Models
PSEN1(M146V) Knock-In
Synonyms: PS1M146V KI, PS1M146VKI, The Miles W. Miller Mouse
NCT00948909
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NCT01626391
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NCT01689246
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NCT01689233
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NCT01039701
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NCT01125683
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NCT01073228
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Research Models
PSEN1 Knock-out
Synonyms: PS1-/-, PS1-, PSEN1 null, Psen1tm1Shn, PS1 null
Species: Mouse
Genes: PSEN1
Modification: PSEN1: Knock-Out
Disease Relevance: Alzheimer's Disease
Strain Name: B6.129-Psen1tm1Shn/J
Summary
These mice are deficient in PSEN1. This model is perinatal lethal in homozygouse animals which die shortly after birth, presumably from breathing difficulties due to ribcage deformity (Shen et al., 1997).
Gross skeletal malformations and central nervous system abnormalities are observed in these animals. Additional phenotypes include: shortened tails that curve to the right, thickened necks, loose skin, hind limbs that curve towards the midline, and reduced body weight.
Last Updated: 16 Jul 2018
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