Species: Mouse
Genes: APP
Modification: APP: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax
Summary
Last Updated: 06 Mar 2018
Further Reading
No Available Further Reading
Species: Mouse
Genes: APP
Modification: APP: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: B6.129S4-Tg(APPSwLon)96Btla/Mmjax
Summary
Last Updated: 25 Nov 2019
Further Reading
No Available Further Reading
Species: Mouse
Genes: APP, PSEN1
Mutations: PSEN1: deltaE9
Modification: APP: Transgenic; PSEN1: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/J
Summary
Phenotype Characterization
When visualized, these models will distributed over a 18 month
timeline
demarcated at the following intervals: 1mo, 3mo, 6mo,
9mo, 12mo, 15mo, 18mo+.
Plaques
Plaques are present in the hippocampus and cortex by 6 months of age.
Cognitive Impairment
Age-related cognitive deficits. Episodic memory appears to be more sensitive than reference memory. No differences at 6 months of age, but detectable at 18 months (Savonenko et al., 2005).
Last Updated: 06 Apr 2022
Further Reading
No Available Further Reading
Species: Mouse
Genes: APP, PSEN1
Modification: APP: Transgenic; PSEN1: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/Mmjax
Summary
Phenotype Characterization
When visualized, these models will distributed over a 18 month
timeline
demarcated at the following intervals: 1mo, 3mo, 6mo,
9mo, 12mo, 15mo, 18mo+.
Plaques
By 9 months of age, amyloid plaques develop in the hippocampus and subiculum, later extending to the cortex (Borchelt et al., 1997). The striatum and thalamus are relatively spared out to 18 months of age. Amyloid pathology is more severe in female mice, with a greater amyloid burden measured at 12 and 17 months of age (Wang et al., 2003).
Neuronal Loss
There was no difference in neuronal numbers in the cingulate cortex compared with wild-type mice (Xiang et al., 2002).
Gliosis
By one year of age, reactive gliosis is observed in the cortex and hippocampus and is associated with dystrophic neurites (Borchelt et al., 1997).
Cognitive Impairment
Age-associated cognitive impairment, as measured by the Morris water maze, was observed in 11 to 12-month-old males. Both acquisition and retention were impaired. No impairment at 3-4 months of age. At both time points mice performed normally on a position discrimination task in the T-maze (Puoliväli et al., 2002).
Last Updated: 29 Nov 2018
Further Reading
No Available Further Reading
Species: Mouse
Genes: PSEN2
Modification: PSEN2: Knock-Out
Disease Relevance: Alzheimer's Disease
Strain Name: B6.129P-Psen2tm1Bdes/J
Summary
Last Updated: 20 Mar 2018
Further Reading
No Available Further Reading
Submitted by elizabethwu1 on 
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