Xu TH, Yan Y, Kang Y, Jiang Y, Melcher K, Xu HE. Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio. Cell Discov. 2016;2:16026. Epub 2016 Aug 23 PubMed.

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Mutations

  1. APP I716T
  2. APP I716V (Florida)