De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, Tang A, Raj T, Replogle J, Brodeur W, Gabriel S, Chai HS, Younkin C, Younkin SG, Zou F, Szyf M, Epstein CB, Schneider JA, Bernstein BE, Meissner A, Ertekin-Taner N, Chibnik LB, Kellis M, Mill J, Bennett DA. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci. 2014 Sep;17(9):1156-63. Epub 2014 Aug 17 PubMed.

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  1. These companion manuscripts report results from two NIA projects supported through the NIH Roadmap Epigenomics Program. They represent an important milestone in Alzheimer’s disease research because they suggest that changes in the DNA methylome may play a role in AD onset and progression and they illustrate that integrating epigenomic data with genomic, RNA expression, neuropathology, and clinical data will be a powerful way to gain new mechanistic insights about the complex etiology of AD.

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