Tran KM, Kwang NE, Butler CA, Gomez-Arboledas A, Kawauchi S, Mar C, Chao D, Barahona RA, Da Cunha C, Tsourmas KI, Shi Z, Wang S, Collins S, Walker A, Shi KX, Alcantara JA, Neumann J, Duong DM, Seyfried NT, Tenner AJ, LaFerla FM, Hohsfield LA, Swarup V, MacGregor GR, Green KN. APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology. Mol Neurodegener. 2025 Jan 22;20(1):9. PubMed.

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Research Models

  1. ApoeCh
  2. ApoeCh x 5xFAD
  3. ApoeCh x PS19
  4. APOE3Ch (Cornell)
  5. APOE3Ch (Cornell) x PS19
  6. APOE3Ch knock-in, floxed (CureAlz)
  7. APOE3Ch knock-in, floxed (CureAlz), tau intracerebral injection
  8. APOE3Ch knock-in, floxed (CureAlz) x APPPS1
  9. APOE3Ch knock-in, floxed (CureAlz) x APPPS1, tau intracerebral injection
  10. APOE4Ch knock-in, floxed (Gladstone)
  11. APOE4Ch knock-in, floxed (Gladstone) x PS19

Mutations

  1. APOE R154S (Christchurch)