Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Yip O, Rao A, Kim MJ, Nelson MR, Wang YH, Grone B, Hao Y, Thomas R, Zilberter M, Yoon SY, Arriola P, Huang Y. APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release. Cell Rep. 2023 Oct 31;42(10):113252. Epub 2023 Oct 19 PubMed.

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Research Models

  1. APOE knock-in, floxed (Gladstone) x PS19
  2. APOE4 knock-in, floxed (Gladstone)
  3. APOE4Ch knock-in, floxed (Gladstone) x PS19