Sjögren M, Davidsson P, Tullberg M, Minthon L, Wallin A, Wikkelso C, Granérus AK, Vanderstichele H, Vanmechelen E, Blennow K. Both total and phosphorylated tau are increased in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001 May;70(5):624-30. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
albumin ratio
(CSF/Blood)		 AD-
Possible Alzheimer's Disease
(19)		 7.9 ± 2.9
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified		 McKhann et al., 1984
albumin ratio
(CSF/Blood)		 AD-
Probable Alzheimer's Disease
(41)		 5.4 ± 1.8
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified		 McKhann et al., 1984
albumin ratio
(CSF/Blood)		 CTRL-
CNC
(17)		 5.3 ± 1.8
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified
albumin ratio
(CSF/Blood)		 CTRL-
CNC
(17)		 5.3 ± 1.8
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified
albumin ratio
(CSF/Blood)		 FTD
(18)		 9.7 ± 2.9
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified		 1994
albumin ratio
(CSF/Blood)		 PD
(15)		 6.8 ± 2.4
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified		 Wallin et al., 1999
albumin ratio
(CSF/Blood)		 VaD
(17)		 11.9 ± 7.2
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified
tau-p181
(CSF)		 AD-
Possible Alzheimer's Disease
(19)		 18.01 ± 5.86
pM		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 AD-
Probable Alzheimer's Disease
(41)		 23.1 ± 10.1
pM		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(17)		 15.9 ± 5.7
pM		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 CTRL-
CNC
(17)		 15.9 ± 5.7
pM		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 FTD
(18)		 8.6 ± 3.9
pM		 ELISA;
Innotest;
Innogenetics		 1994
tau-p181
(CSF)		 PD
(15)		 14.1 ± 3.1
pM		 ELISA;
Innotest;
Innogenetics		 Wallin et al., 1999
tau-p181
(CSF)		 VaD
(17)		 6.4 ± 5.6
pM		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 AD-
Possible Alzheimer's Disease
(19)		 16.34 ± 4.3
pM		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 AD-
Probable Alzheimer's Disease
(41)		 20 ± 7.6
pM		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(17)		 8.3 ± 2.8
pM		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 CTRL-
CNC
(17)		 8.3 ± 2.8
pM		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 FTD
(18)		 9.7 ± 2.9
pM		 ELISA;
Innotest;
Innogenetics		 1994
tau-total
(CSF)		 PD
(15)		 7.5 ± 1.6
pM		 ELISA;
Innotest;
Innogenetics		 Wallin et al., 1999
tau-total
(CSF)		 VaD
(17)		 3.7 ± 2.3
pM		 ELISA;
Innotest;
Innogenetics

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This paper appears in the following:

News

  1. Tau Biomarkers—More Informative Fragments in Spinal Fluid?
  2. Better Diagnosis with Blood Test Detecting Only Tau Made in Brain

AlzBiomarker

  1. AD vs CTRL : albumin ratio (CSF)
  2. CTRL vs AD : albumin ratio (CSF)
  3. FTD vs AD : albumin ratio (CSF)
  4. PD vs AD : albumin ratio (CSF)
  5. VaD vs AD : albumin ratio (CSF)
  6. AD vs CTRL : tau-p181 (CSF)
  7. CTRL vs AD : tau-p181 (CSF)
  8. FTD vs AD : tau-p181 (CSF)
  9. PD vs AD : tau-p181 (CSF)
  10. VaD vs AD : tau-p181 (CSF)
  11. AD vs CTRL : tau-total (CSF)
  12. CTRL vs AD : tau-total (CSF)
  13. FTD vs AD : tau-total (CSF)
  14. PD vs AD : tau-total (CSF)
  15. VaD vs AD : tau-total (CSF)