Dehury B, Somavarapu AK, Kepp KP. A computer-simulated mechanism of familial Alzheimer's disease: Mutations enhance thermal dynamics and favor looser substrate-binding to γ-secretase. J Struct Biol. 2020 Dec 1;212(3):107648. Epub 2020 Oct 21 PubMed.

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Mutations

  1. APP V717I (London)
  2. PSEN1 E280A (Paisa)
  3. PSEN1 G384A
  4. PSEN1 A434C
  5. PSEN1 L435F