Alves G, Brønnick K, Aarsland D, Blennow K, Zetterberg H, Ballard C, Kurz MW, Andreasson U, Tysnes OB, Larsen JP, Mulugeta E. CSF amyloid-beta and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: the Norwegian ParkWest study. J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1080-6. Epub 2010 Jun 14 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ38
(CSF)		 AD
(20)		 514 ± 267
pg/mL		 Electrochemiluminescence;
MSD 4G8;
Meso Scale Discovery		 McKhann et al., 1984
Aβ38
(CSF)		 CTRL-
CNC
(36)		 629 ± 332
pg/mL		 Electrochemiluminescence;
MSD 4G8;
Meso Scale Discovery
Aβ38
(CSF)		 PD
(109)		 484 ± 328
pg/mL		 Electrochemiluminescence;
MSD 4G8;
Meso Scale Discovery		 Gelb et al., 1999
Aβ40
(CSF)		 AD
(20)		 6104 ± 1505
pg/mL		 Electrochemiluminescence;
MSD 4G8;
Meso Scale Discovery		 McKhann et al., 1984
Aβ40
(CSF)		 CTRL-
CNC
(36)		 7070 ± 2432
pg/mL		 Electrochemiluminescence;
MSD 4G8;
Meso Scale Discovery
Aβ40
(CSF)		 PD
(109)		 5973 ± 2265
pg/mL		 Electrochemiluminescence;
MSD 4G8;
Meso Scale Discovery		 Gelb et al., 1999
Aβ42
(CSF)		 AD
(20)		 208 ± 78
pg/mL		 Electrochemiluminescence;
MSD 4G8;
Meso Scale Discovery		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(36)		 445 ± 223
pg/mL		 Electrochemiluminescence;
MSD 4G8;
Meso Scale Discovery
Aβ42
(CSF)		 PD
(109)		 362 ± 192
pg/mL		 Electrochemiluminescence;
MSD 4G8;
Meso Scale Discovery		 Gelb et al., 1999
tau-p181
(CSF)		 AD
(20)		 89 ± 36
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(36)		 51 ± 23
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 PD
(109)		 58 ± 38
pg/mL		 ELISA;
Innotest;
Innogenetics		 Gelb et al., 1999
tau-total
(CSF)		 AD
(20)		 435 ± 217
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(36)		 228 ± 110
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 PD
(109)		 224 ± 117
pg/mL		 ELISA;
Innotest;
Innogenetics		 Gelb et al., 1999

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This paper appears in the following:

News

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AlzBiomarker

  1. AD vs CTRL : Aβ38 (CSF)
  2. CTRL vs AD : Aβ38 (CSF)
  3. PD vs AD : Aβ38 (CSF)
  4. AD vs CTRL : Aβ40 (CSF)
  5. CTRL vs AD : Aβ40 (CSF)
  6. PD vs AD : Aβ40 (CSF)
  7. AD vs CTRL : Aβ42 (CSF)
  8. CTRL vs AD : Aβ42 (CSF)
  9. PD vs AD : Aβ42 (CSF)
  10. AD vs CTRL : tau-p181 (CSF)
  11. CTRL vs AD : tau-p181 (CSF)
  12. PD vs AD : tau-p181 (CSF)
  13. AD vs CTRL : tau-total (CSF)
  14. CTRL vs AD : tau-total (CSF)
  15. PD vs AD : tau-total (CSF)