Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y. Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. J Biol Chem. 2006 May 26;281(21):14776-86. PubMed.

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    • User Profile Image Bart De Strooper
      UK Dementia Research Institute@UCL and VIB@KuLeuven
    • Posted:

    This paper sets the standard for gamma-secretase assays. The paper is also the last one in a nice series of publications of this group that convincingly demonstrates that gamma-secretase progressively cleaves APP protein starting from the epsilon cleavage down to the gamma-sites.

    View all comments by Bart De Strooper

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