Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, Levitch D, Taylor-Reinwald L, Gitcho M, Tu PH, Tenenholz Grinberg L, Liscic RM, Armendariz J, Morris JC, Goate AM. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Ann Neurol. 2006 Sep;60(3):314-22. PubMed.
Recommends
Please login to recommend the paper.
Comments
University of Pennsylvania
This study extends the findings on progranulin to include the HDD2 (hereditary dysphasic disinhibition dementia) family, thereby solving yet another important unsolved mystery about frontotemporal dementias.
Make a Comment
To make a comment you must login or register.