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Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ. Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol. 2000 Oct;48(4):567-79. PubMed.
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Columbia University
These add strong support to the notion that therapy targeting amyloid-beta may be an effective treatment for Alzheimer's disease.
Please see the following comments related to this article: Alzheimer’s anti-amyloid vaccination and statins: two approaches, one dogma. The time for change. Koudinov and Koudinova BMJ 20 March 2002 [ Full Text ] Alzheimer's disease and amyloid beta protein Koudinov AR et al Science online,> Published 25 June 2002 [ Full Text ] Dangers of the amyloid-beta vaccination. Smith MA et al. Acta Neuropathol (Berl) 2002 Jul;104(1):110 [ PubMed ] Call for Elan to publish Alzheimer's trial details Bishop et al. Nature. 416(6882): 677, 2002 Apr 18. [ PubMed ]
References:
Smith MA, Joseph JA, Atwood CS, Perry G. Dangers of the amyloid-beta vaccination. Acta Neuropathol. 2002 Jul;104(1):110. PubMed.
Bishop GM, Robinson SR, Smith MA, Perry G, Atwood CS. Call for Elan to publish Alzheimer's trial details. Nature. 2002 Apr 18;416(6882):677. PubMed.
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