Paper
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Berezovska O, Jack C, Deng A, Gastineau N, Rebeck GW, Hyman BT. Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage. J Biol Chem. 2001 Aug 10;276(32):30018-23. Epub 2001 Jun 14 PubMed.
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Comments
Osaka City University Medical School
"This may suggests an important clue to understand the physiological interaction, though indirect, between APP and Notch as the common substrate for PS. It must be co crucial if the PS content as an enzyme is constant. However, it still remains if the PS content in development stage and pathological stage."
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