Naguib S, Lopez-Lee C, Torres ER, Lee SI, Zhu J, Zhu D, Ye P, Norman K, Zhao M, Wong MY, Ambaw YA, Muñoz-Castañeda R, Wang W, Patel T, Bhagwat M, Norinsky R, Mok SA, Walther TC, Farese RV Jr, Luo W, Sinha SC, Wu Z, Fan L, Gong S, Gan L. The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway. Immunity. 2025 Jun 18; Epub 2025 Jun 18 PubMed.

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Research Models

  1. APOE3 knock-in (Cornell)
  2. APOE3Ch (Cornell)
  3. APOE3Ch (Cornell) x PS19
  4. ApoeCh
  5. ApoeCh x 5xFAD
  6. ApoeCh x PS19
  7. APOE3Ch knock-in, floxed (CureAlz)
  8. APOE3Ch knock-in, floxed (CureAlz), tau intracerebral injection
  9. APOE3Ch knock-in, floxed (CureAlz) x APPPS1
  10. APOE3Ch knock-in, floxed (CureAlz) x APPPS1, tau intracerebral injection
  11. APOE4Ch knock-in, floxed (Gladstone)
  12. APOE4Ch knock-in, floxed (Gladstone) x PS19