Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD. Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol. 1998 Jun;43(6):815-25. PubMed.

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Mutations

  1. MAPT D285N
  2. MAPT D285D
  3. MAPT V289A
  4. MAPT V337M
  5. MAPT N255N
  6. MAPT Y441H
  7. MAPT S447P
  8. MAPT P301L

Research Timeline Event

  1. Tau mutations cause neurofibrillary pathology, neurodegeneration, FTD, but not AD