Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, von Saucken VE, Williams RY, Karlo JC, Moutinho M, Xu G, Ransohoff RM, Lamb BT, Landreth GE. The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease. Mol Neurodegener. 2018 Jun 1;13(1):29. PubMed.

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This paper appears in the following:

Research Models

  1. Trem2 R47H KI (Lamb/Landreth)
  2. Trem2 R47H KI (Lamb/Landreth) X APPPS1-21

Mutations

  1. TREM2 R47H

News

  1. Model Morass? R47H Mutation Scuttles TREM2 Expression in Mice, Not People
  2. Boost or Block TREM2? Either Way, Therapy May Need Careful Timing