Research Models

PSEN1(WT)

Synonyms: PS1(WT), PSEN1 (wild-type)

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Species: Mouse
Genes: PSEN1
Modification: PSEN1: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: Mixed C57BL/6J, DBA/2J
Availability: No longer available

Summary

These mice express wild-type human PSEN1. Compared with mice expressing similar levels of human PSEN1 with the P117L mutation (i.e. PSEN1(P117L), expression of wild-type PSEN1 was associated with increased survival and differentiation of neural progenitor cells in the hippocampus, leading to the generation of more immature granule cells (Wen et al., 2002).

Modification Details

Human wild-type PSEN1 driven by neuron-specific enolase (NSE).

Last Updated: 06 Mar 2018

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References

Research Models Citations

  1. PSEN1(P117L) (line 13)

Paper Citations

  1. Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiol Dis. 2002 Jun;10(1):8-19. PubMed.

Further Reading

Papers

  1. Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Exp Neurol. 2004 Aug;188(2):224-37. PubMed.