Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| ABvac40 | Alzheimer's Disease (Phase 2) | Araclon Biotech | Amyloid-Related | Immunotherapy (active) | ||
| ACI-24.060 | ACI-24, Pal1-15 acetate salt |
Alzheimer's Disease (Phase 2), Down's Syndrome (Phase 2) | AC Immune SA, Takeda Pharmaceutical Company | Amyloid-Related | Immunotherapy (active) | |
| Acitretin | Soriatane , Neotigason, RO 101670 |
Alzheimer's Disease (Phase 2) | Actavis, Allergan plc | Amyloid-Related | Small Molecule | Psoriasis in US |
| Bexarotene | Targretin® | Alzheimer's Disease (Phase 2) | Ligand Pharmaceuticals, Inc., ReXceptor Inc. | Amyloid-Related, Unknown | Small Molecule | Cutaneous T-cell Lymphoma in US |
| CHF 5074 | Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) | CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. | Amyloid-Related, Inflammation, Other | Small Molecule | ||
| Epigallocatechin Gallate (EGCG) | Sunphenon EGCg | Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) | Taiyo International | Amyloid-Related, Inflammation, Other | Supplement, Dietary | |
| Lenalidomide | Revlimid | Alzheimer's Disease (Phase 2) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | Multiple myeloma, lymphoma, myelodysplastic syndromes |
| Levetiracetam | Keppra | Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) | UCB S.A. | Amyloid-Related, Other | Small Molecule | Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries |
| Lithium | lithium carbonate, lithium aspartate, lithium citrate, lithium orotate |
Alzheimer's Disease (Phase 4), Amyotrophic Lateral Sclerosis (Phase 3), Frontotemporal Dementia (Inactive), Mild Cognitive Impairment (Phase 4), Parkinson's Disease (Phase 2) | Amyloid-Related, Tau, Metals, Other | Other | Bipolar disorder | |
| Mivelsiran | ALN-APP | Alzheimer's Disease (Phase 1), Cerebral Amyloid Angiopathy (Phase 2) | Alnylam Pharmaceuticals, Inc. | Amyloid-Related | DNA/RNA-based | |
| Nasal Insulin | Detemir, Levemir, Humulin, Novolin, glulisine |
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) | Amyloid-Related, Other | Small Molecule, Other | Diabetes | |
| NIC5-15 | Pinitol, D-Pinitol |
Alzheimer's Disease (Phase 2) | Humanetics Pharmaceuticals Corporation | Amyloid-Related, Other | Small Molecule, Supplement, Dietary | |
| SHR-1707 | Alzheimer's Disease (Phase 2) | Amyloid-Related | Immunotherapy (passive) | |||
| Troculeucel | SNK01 | Alzheimer's Disease (Phase 2) | NKGen Biotech, Inc. | Amyloid-Related, Inflammation | Other | |
| UB-311 | Alzheimer's Disease (Phase 2) | United Neuroscience, Vaxxinity | Amyloid-Related | Immunotherapy (active) | ||
| VHB937 | Alzheimer's Disease (Phase 1), Amyotrophic Lateral Sclerosis (Phase 2) | Novartis Pharmaceuticals Corporation | Amyloid-Related | Immunotherapy (passive) | ||
| Zervimesine | CT1812 , Elayta |
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Cognition Therapeutics Inc. | Amyloid-Related | Small Molecule |