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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| AQW051 | Alpha-7 nicotinic acetylcholine receptor agonist | Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 2), Schizophrenia (Phase 2) | Novartis Pharmaceuticals Corporation | Cholinergic System | Small Molecule | |
| AZD3480 | ispronicline, TC-1734 |
Alzheimer's Disease (Inactive) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | |
| Donepezil | Aricept™, Donepezil hydrochloride, Eranz®, E 2020 |
Alzheimer's Disease (Approved), Dementia with Lewy Bodies (Inactive), Down's Syndrome (Inactive), Parkinson's Disease Dementia (Inactive) | Corium, Inc., Eisai Co., Ltd., Pfizer | Cholinergic System | Small Molecule | Alzheimer's Disease, Dementia with Lewy Bodies (Japan) |
| HTL0018318 | Alzheimer's Disease (Inactive), Dementia with Lewy Bodies (Inactive) | Allergan plc, Sosei Heptares | Cholinergic System | Small Molecule | ||
| Huperzine A | ZT-1, DEBIO 9902 , Qian ceng ta, Cerebra capsule, Pharmassure Memorall capsule |
Alzheimer's Disease (Inactive) | Debiopharm Group™, Neuro-Hitech, Inc. | Cholinergic System | Small Molecule, Supplement, Dietary | None |
| Nelonicline | ABT-126 | Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | AbbVie | Cholinergic System | Small Molecule | |
| Phenserine | Alzheimer's Disease (Inactive) | Annovis Bio, TorreyPines Therapeutics, Inc. | Cholinergic System | Small Molecule | ||
| RG3487 | RO5313534, MEM 3454 |
Alzheimer's Disease (Inactive) | Cholinergic System | Small Molecule |