Reelin Variant Wards Off Dementia in Colombian Kindred Siblings
An amino acid change in this ApoE receptor-binding protein may have bestowed 20 years of resilience to a brother and sister carrying the presenilin Paisa mutation.
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Amyloid Jungle: Plaque Fibrils Mesh With All Manner of Vesicles, Membranes
Arranged in bundles and lattices within a plaque, Aβ42 fibrils were intermixed with extracellular vesicles of different shapes and sizes. Their origin remains unknown.
Direct-to-Consumer Alzheimer’s Blood Test Opens Pandora’s Box
Experts say the low specificity of Quest Diagnostics’ plasma Aβ test could lead to more false than true positives, causing distress and confusion.
Patricidal Protein? Aβ42 said to Inhibit Its Parent, γ-Secretase
At high concentrations, Aβ42 gums up the protease’s active site. A new theory explains how γ-secretase modulators work. One is en route to Phase 2.
More Evidence that Locus Coeruleus Demise Precedes Cortical Tangles
People who had a damaged locus coeruleus accumulated tangles in their medial temporal lobes over the next three years, and their cognition declined.
Do Two APOE4 Alleles Always Mean Alzheimer's?
By age 65, nearly all people who carry two copies of APOE4 harbor neuropathological or biomarker evidence of AD pathology.
Donanemab Approval Likely to Pose New Quandaries for Clinicians
With limited guidance, physicians will have to navigate questions about whom to treat, when to stop, and how to manage safety.
T Cells in the Brain Goad Microglia to Muddle Myelin
In mouse models of amyloidosis, CD8+ T cells trigger myelin pathology by rousing microglia and confusing oligodendrocytes.
Amyloid Plaques Turn More Toxic as They Age
Combining isotopic labeling and transcriptomics, scientists found that mature plaques in mice wreaked more havoc on surrounding synapses than immature ones.
Remembering Bruce Albala, 70, Leader in BACE Inhibitor Development
Albala died suddenly while celebrating his 40th wedding anniversary.
Is Your Brain Aging Fast? Plasma Proteins Might Tell
Eight proteins in blood associate with faster brain aging, five with slower. The extracellular matrix protein brevican comes with larger cortical volume, lower dementia odds.
New Biomarkers Catch Tau Before It Tangles
Scientists characterize early stage tau aggregates and develop a CSF test to track them.
Hot News: DIAN Participant Defies Presenilin 2 Mutation
The man has lots of plaques but few tangles 18 years after his expected age of onset; potential protective factors include extensive heat shock protein expression.
Blood Tests Forecast Dementia in Down’s Syndrome
Rising plasma p-tau217 precedes cognitive decline in Trisomy 21. GFAP flags future amyloid buildup.
The Alzheimer's Vaccination Story, Continued
Two papers advance the drive to develop an Alzheimer's vaccine, one looking at the antibody response in some of the Elan trial participants, the other using sophisticated methods to analyze the epitope recognized by antibodies generated in response to Aβ42 immunization.
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