Vanderstichele H, De Meyer G, Andreasen N, Kostanjevecki V, Wallin A, Olsson A, Blennow K, Vanmechelen E. Amino-truncated beta-amyloid42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment. Clin Chem. 2005 Sep;51(9):1650-60. Epub 2005 Jul 14 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(66)		 392 ± 141
ng/L §		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(29)		 832 ± 191
ng/L §		 ELISA;
Innotest;
Innogenetics
Aβ42
(CSF)		 DLB
(15)		 485 ± 204
ng/L §		 ELISA;
Innotest;
Innogenetics		 McKeith et al., 1996
Aβ42
(CSF)		 MCI-AD
(15)		 579 ± 263
ng/L §		 ELISA;
Innotest;
Innogenetics		 Petersen et al., 1999; McKhann et al., 1984
Aβ42
(CSF)		 MCI-Stable
(26)		 633 ± 226
ng/L §		 ELISA;
Innotest;
Innogenetics		 Petersen et al., 1999
Aβ42
(CSF)		 PD
(15)		 673 ± 123
ng/L §		 ELISA;
Innotest;
Innogenetics		 Hughes et al., 1992
tau-p181
(CSF)		 AD
(65)		 197 ± 81
ng/L §		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(29)		 86 ± 44
ng/L §		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 DLB
(15)		 110 ± 38
ng/L §		 ELISA;
Innotest;
Innogenetics		 McKeith et al., 1996
tau-p181
(CSF)		 MCI-AD
(15)		 191 ± 88
ng/L §		 ELISA;
Innotest;
Innogenetics		 Petersen et al., 1999; McKhann et al., 1984
tau-p181
(CSF)		 MCI-Stable
(26)		 78 ± 32
ng/L §		 ELISA;
Innotest;
Innogenetics		 Petersen et al., 1999
tau-p181
(CSF)		 PD
(15)		 79 ± 19
ng/L §		 ELISA;
Innotest;
Innogenetics		 Hughes et al., 1992
tau-total
(CSF)		 AD
(66)		 394 ± 159
ng/L §		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(29)		 240 ± 103
ng/L §		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 DLB
(15)		 218 ± 107
ng/L §		 ELISA;
Innotest;
Innogenetics		 McKeith et al., 1996
tau-total
(CSF)		 MCI-AD
(15)		 374 ± 131
ng/L §		 ELISA;
Innotest;
Innogenetics		 Petersen et al., 1999; McKhann et al., 1984
tau-total
(CSF)		 MCI-Stable
(26)		 179 ± 79
ng/L §		 ELISA;
Innotest;
Innogenetics		 Petersen et al., 1999
tau-total
(CSF)		 PD
(15)		 208 ± 52
ng/L §		 ELISA;
Innotest;
Innogenetics		 Hughes et al., 1992

§ Data supplied to Alzforum by author

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AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. DLB vs AD : Aβ42 (CSF)
  4. MCI-AD vs MCI-Stable : Aβ42 (CSF)
  5. PD vs AD : Aβ42 (CSF)
  6. AD vs CTRL : tau-p181 (CSF)
  7. CTRL vs AD : tau-p181 (CSF)
  8. DLB vs AD : tau-p181 (CSF)
  9. MCI-AD vs MCI-Stable : tau-p181 (CSF)
  10. PD vs AD : tau-p181 (CSF)
  11. AD vs CTRL : tau-total (CSF)
  12. CTRL vs AD : tau-total (CSF)
  13. DLB vs AD : tau-total (CSF)
  14. MCI-AD vs MCI-Stable : tau-total (CSF)
  15. PD vs AD : tau-total (CSF)