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CONFERENCE COVERAGE 2023-07-29 Conference Coverage Scientists once hoped that blocking β-secretase would slow or prevent Alzheimer’s disease. Then came the rude awakening. The inhibitors caused the very thing they were supposed to prevent—cognitive decline. Enthusiasm tanked. Pharmaceu
RESEARCH NEWS 2021-10-09 Research News APOE4, the strongest genetic risk factor for sporadic Alzheimer’s disease, has been tied to slightly better memory in the young. Now, researchers led by Sebastian Crutch and Jonathan Schott, University College London, find a similar benefit
RESEARCH NEWS 2021-10-07 Research News Astrocytes support neurons in the brain but occasionally turn on them, releasing a long-sought mystery substance that kills not only neurons but oligodendrocytes as well. More than 10 years after discovering this phenomenon, scientists still
RESEARCH NEWS 2021-10-06 Research News After decades of nonstarters, blood tests for Alzheimer’s disease are finally here, enabling researchers to predict who may have amyloid plaques in their brain. Among the candidate tests jostling for attention, are some better than others? R
RESEARCH NEWS 2021-10-05 Research News A diverse bunch of neurodegenerative diseases, tauopathies are marked by a range of clinical manifestations and of neuropathological hallmarks. According to a study published September 29 in Nature, the defining feature of each type of tauop
RESEARCH NEWS 2021-10-02 Research News The FDA approved aducanumab based on biomarker data hoping the drug will eventually improve clinical outcomes. Like many in the field, the agency reasons that because brain amyloid deposition precedes cognitive decline, removing amyloid will
RESEARCH NEWS 2021-10-01 Research News A rare APOE3 variant, dubbed APOE3-Jacksonville, drastically reduces a person's risk of developing Alzheimer’s disease. How does it protect the brain? Primarily by reducing ApoE self-aggregation, according to scientists led by Guojun Bu
RESEARCH NEWS 2021-10-01 Research News Scientists agree that Aβ oligomers damage synapses, but their exact role in Alzheimer’s disease has been maddeningly hard to pin down because they are extremely difficult to detect. In the September 22 Alzheimer’s & Dementia, researchers
RESEARCH NEWS 2021-09-30 Research News It takes a village—of microglia, that is—to vanquish the scourge of α-synuclein aggregates. That’s the upshot of a paper published September 21 in Cell. Led by Michael Heneka of the German Center for Neurodegenerative Diseases in Bonn, scien
RESEARCH NEWS 2021-09-28 Research News How soon will a person with amyloid plaques in the brain develop the symptoms of late-onset Alzheimer’s disease? In the September 9 Neurology, researchers led by Suzanne Schindler at Washington University in St. Louis debuted a method for an
COMMUNITY NEWS 2021-09-24 Community News Conceived at the World Economic Forum in January 2021, a group calling itself the Davos Alzheimer’s Collaborative is attempting to globalize Alzheimer's disease research and trials. DAC is a partnership between industry, academia, gove
RESEARCH NEWS 2021-09-23 Research News Tau aggregation begins not in the cortex, but in the brainstem. Does tangle deposition in the locus coeruleus, which often starts in a person’s 30s, presage Alzheimer’s disease? In the September 22 Science Translational Medicine, researchers
RESEARCH NEWS 2021-09-23 Research News When astrocytes transform from homeostatic to reactive, what goes wrong inside them? Martin Kampmann, University of California, San Francisco, and colleagues blame dysfunctional lysosomes. In a bioRxiv preprint uploaded on September 12, the
RESEARCH NEWS 2021-09-18 Research News Do people who live into their late 90s and beyond simply carry no pathogenic gene variants, or are they blessed with variants that stave off age-related disease? It's a little bit of both, but more of the latter. That's according t
RESEARCH NEWS 2021-09-17 Research News The spread of tau pathology from the entorhinal cortex into the neighboring hippocampus region of the brain is thought to herald the onset of clinical symptoms in AD, but exactly what path does tau take from one region to the next? Both, aft
