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RESEARCH NEWS 2021-09-16 Research News It took more than a million samples, but researchers have managed to extract seven fresh AD risk loci from a genome-wide association study. Published September 7 in Nature Genetics, this GWAS included 90,338 samples from people who were eith
RESEARCH NEWS 2021-09-14 Research News Tau aggregates are known to bind proteins and RNAs. Could this be why tangles are toxic? Researchers led by Benjamin Wolozin at Boston University think so. In the August 27 Molecular Cell, they reported that the RNA-binding protein HNRNPA2B1
RESEARCH NEWS 2021-09-10 Research News Alzheimer’s researchers are making more use than ever of human induced pluripotent stem cell lines to model the disease. But how well do iPSCs generated from people with late-onset AD really reflect brain biology? In the August 26 Neuron onl
RESEARCH NEWS 2021-09-10 Research News People who log seven to eight hours of sleep per night have less amyloid and perform better on memory and other tests than do people who reported sleeping for six hours or less. This is the main finding from a study published August 30 in JA
COMMUNITY NEWS 2021-09-09 Community News Today, the National Institute on Aging announced that it will fund two new Alzheimer’s Disease Research Centers, bringing the total number to 33. Duke University, Durham, and the University of North Carolina, Chapel Hill, will coordinate th
RESEARCH NEWS 2021-09-03 Research News In the Alzheimer’s cascade hypothesis, plaques unleash tangles; alas, where neuroinflammation fits in has been hazy. Now, the first study to combine imaging of microglial activation with amyloid and tau PET in the human brain places neuroinf
CONFERENCE COVERAGE 2021-09-03 Conference Coverage Does COVID-19 increase the risk of dementia? While that will take decades to answer, researchers are beginning to unravel how this disease might injure the brain. At the Alzheimer’s Association International Conference held in July in
RESEARCH NEWS 2021-09-03 Research News That Aβ begets tau pathology is the central premise of the amyloid cascade hypothesis of Alzheimer’s disease. But how exactly does the begetting happen? A paper published August 31 in Cell Reports posits that a crisis of synaptic strength li
RESEARCH NEWS 2021-09-02 Research News In a first for the field, there is now a hint that a tau immunotherapy may have slightly benefited people with Alzheimer’s disease. Semorinemab, a monoclonal antibody specific for tau’s N-terminus, stemmed cognitive decline by almost half am
CONFERENCE COVERAGE 2021-08-27 Conference Coverage At last month's Alzheimer’s Association International Conference, scientists showed new data that confirms phospho-tau231 as one of the earliest biomarkers known to rise in the plasma of people with preclinical Alzheimer’s disease
RESEARCH NEWS 2021-08-27 Research News Staying active has many health benefits, including, perhaps, to help preserve memory. Alas, is this true in some more than others? Scientists led by Kumar Rajan at Rush University, Chicago, suggest as much in the August 11 JAMA Network Open.
RESEARCH NEWS 2021-08-27 Research News As the brain ages, the insulating myelin sheath around axons begins to degrade. Could this white-matter degeneration trigger Alzheimer’s disease? In a preprint on bioRXiv, researchers led by Constanze Depp and Klaus-Armin Nave at the Max Pla
CONFERENCE COVERAGE 2021-08-27 Conference Coverage Mere responders no more, microglia nowadays are respected—if not feared—as early actors when a person is developing a neurodegenerative disease. Several presentations at last month’s Alzheimer’s Association International Conference und
RESEARCH NEWS 2021-08-24 Research News Researchers have a new entrant to the pantheon of pathogenic APP mutations. The Uppsala mutation, identified in one Swedish family, is the first known multi-codon deletion in the gene to lead to Alzheimer’s disease. It snips six amino acids,
CONFERENCE COVERAGE 2021-08-20 Conference Coverage At this year’s Alzheimer’s Association International Conference, scientists reported the first substantial single-nucleus RNA-Seq analysis of brain tissue from people who had had familial Alzheimer’s disease. They found subclusters amo
