Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| ACI-3024 | Tau MorphomerTM | Alzheimer's Disease (Inactive), Other Tauopathy (Phase 0) | AC Immune SA | Tau | Small Molecule | |
| AQW051 | Alpha-7 nicotinic acetylcholine receptor agonist | Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 2), Schizophrenia (Phase 2) | Novartis Pharmaceuticals Corporation | Cholinergic System | Small Molecule | |
| ASN51 | ASN121151 | Alzheimer's Disease (Inactive) | Asceneuron SA | Tau | Small Molecule | |
| Atorvastatin | Lipitor™ , Zarator®, Sortis®, Tahor® |
Alzheimer's Disease (Inactive) | Pfizer | Cholesterol | Small Molecule | Hypercholesterolaemia |
| AZD3480 | ispronicline, TC-1734 |
Alzheimer's Disease (Inactive) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | |
| CHF 5074 | Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) | CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. | Amyloid-Related, Inflammation, Other | Small Molecule | ||
| Citalopram | escitalopram, Celexa, Lexapro , Cipralex |
Alzheimer's Disease (Phase 3), Preclinical Alzheimer's Disease (Inactive) | Other Neurotransmitters | Small Molecule | Depression, generalized anxiety disorder | |
| Dapsone | Avlosulfon, Diaminodiphenylsulfone, DDS |
Alzheimer's Disease (Inactive) | Immune Network Ltd. | Other | Small Molecule | Leprosy, malaria, some bacterial skin infections |
| DNL201 | Parkinson's Disease (Inactive) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | ||
| DNL747 | SAR443060 | Alzheimer's Disease (Inactive), Amyotrophic Lateral Sclerosis (Inactive) | Denali Therapeutics Inc., Sanofi | Inflammation | Small Molecule | |
| Donepezil | Aricept™, Donepezil hydrochloride, Eranz®, E 2020 |
Alzheimer's Disease (Approved), Dementia with Lewy Bodies (Inactive), Down's Syndrome (Inactive), Parkinson's Disease Dementia (Inactive) | Corium, Inc., Eisai Co., Ltd., Pfizer | Cholinergic System | Small Molecule | Alzheimer's Disease, Dementia with Lewy Bodies (Japan) |
| ELND005 | AZD-103, Scyllo-inositol, cyclohexane-1,2,3,4,5,6-hexol |
Alzheimer's Disease (Inactive) | Elan Corporation, Opko Health, Speranza Therapeutics, Transition Therapeutics, Inc. | Amyloid-Related | Small Molecule | None |
| Exenatide | Exendin-4, Byetta, Bydureon |
Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 3) | AstraZeneca, Eli Lilly & Co. | Other | Small Molecule | Diabetes mellitus in US |
| GV-971 | sodium oligomannate, sodium oligo-mannurarate |
Alzheimer's Disease (Inactive) | Shanghai Green Valley Pharmaceuticals | Amyloid-Related, Inflammation | Small Molecule | |
| HTL0018318 | Alzheimer's Disease (Inactive), Dementia with Lewy Bodies (Inactive) | Allergan plc, Sosei Heptares | Cholinergic System | Small Molecule | ||
| Huperzine A | ZT-1, DEBIO 9902 , Qian ceng ta, Cerebra capsule, Pharmassure Memorall capsule |
Alzheimer's Disease (Inactive) | Debiopharm Group™, Neuro-Hitech, Inc. | Cholinergic System | Small Molecule, Supplement, Dietary | None |
| Idalopirdine | Lu AE58054, SGS 518 |
Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| MKC-231 | Alzheimer's Disease (Inactive) | Mitsubishi Tanabe Pharma | Unknown | Small Molecule | None | |
| Nelonicline | ABT-126 | Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | AbbVie | Cholinergic System | Small Molecule | |
| Nilotinib | Tasigna, AMN107 |
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Inactive) | KeifeRx | Other | Small Molecule | Chronic myeloid leukemia |
| Nilvadipine | Nilvad, Nivadil, ARC029 |
Alzheimer's Disease (Inactive) | Archer Pharmaceuticals, Inc. | Other | Small Molecule | |
| PBT2 | PBT-2 | Alzheimer's Disease (Inactive), Huntington's Disease (Inactive) | Alterity Therapeutics | Amyloid-Related, Metals | Small Molecule | |
| Phenserine | Alzheimer's Disease (Inactive) | Annovis Bio, TorreyPines Therapeutics, Inc. | Cholinergic System | Small Molecule | ||
| Pridopidine | ACR16, TV-7820, Huntexil, ASP2314 |
Amyotrophic Lateral Sclerosis (Phase 2/3), Huntington's Disease (Phase 3), Parkinson's Disease (Inactive) | Prilenia Therapeutics | Other | Small Molecule | |
| PRX-03140 | Potassium salt | Alzheimer's Disease (Inactive) | Epix Pharmaceuticals | Other | Small Molecule | |
| Rasagiline | Rasagiline mesylate, Azilect, TVP-1012 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) | Teva | Other Neurotransmitters | Small Molecule | |
| Relyvrio | Albrioza, AMX0035 |
Amyotrophic Lateral Sclerosis (Withdrawn), Alzheimer's Disease (Inactive), Progressive Supranuclear Palsy (Discontinued) | Amylyx Pharmaceuticals Inc | Other | Combination, Small Molecule | ALS |
| RG3487 | RO5313534, MEM 3454 |
Alzheimer's Disease (Inactive) | Cholinergic System | Small Molecule | ||
| Sabeluzole | R58735 | Alzheimer's Disease (Inactive) | Unknown | Small Molecule | ||
| Simvastatin | Zocor®, Lipex®, Lipovas®, Denan® |
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Phase 4) | Merck | Cholesterol | Small Molecule | Hypercholesterolemia and diabetic cardiomyopathy. |
| ST101 | ZSET1446 | Alzheimer's Disease (Inactive) | Sonexa Therapeutics, Inc. | Unknown | Small Molecule | |
| TPI 287 | Alzheimer's Disease (Inactive), Corticobasal Degeneration (Inactive), Progressive Supranuclear Palsy (Phase 1) | Cortice Biosciences | Tau | Small Molecule | ||
| Valproate | Depakote, Depakene, Valproic acid , Divalproex sodium |
Alzheimer's Disease (Inactive) | Abbott Laboratories | Other Neurotransmitters | Small Molecule | Epilepsy, Bipolar disorder, Migraine |
| Venglustat | Ibiglustat, GZ/SAR402671, Genz-682452 |
Parkinson's Disease (Inactive) | Genzyme, Sanofi | alpha-synuclein, Other | Small Molecule |