New Role for Tau: Making Lipid Droplets in Glia?
Glia need just the right amount of tau for lipid droplets to bud from the endoplasmic reticulum. These soak up toxic lipids spilled by stressed neurons.
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Lecanemab Tops Other Antibodies at Binding Soluble Aβ Aggregates
In a head-to-head comparison with aducanumab, gantenerumab, and donanemab, lecanemab demonstrated the highest affinity, especially for smaller aggregates.
Can Heparin Delay Alzheimer’s Disease?
In two hospital systems, people who received heparin were diagnosed with AD a year later than people who never took the anticoagulant.
Data Fabrication Ousted NIA Neuroscience Director Eliezer Masliah
The NIH removed Masliah from his post after an investigation found two publications with falsified data. At least 130 more papers with 500 co-authors face allegations.
Large Neuropathology GWAS Finds Four New Dementia Genes
The analysis of nearly 8,000 brains turned up three genes linked to cerebrovascular disease, and one linked to tangles.
Repeat Expansion Mutations More Common Than Thought
A whole-genome sequencing study estimated that people are two to three times more likely to be affected by these mutations than predicted by epidemiology.
Do Overloaded Microglia Smother Stressed Neurons?
In mice with prion disease, microglia shifted from gobbling up misfolded protein to engulfing flagging neurons. This change coincided with symptom onset.
Reconceptualizing the BBB: Is It Time to Swap ‘Barrier’ for ‘Border'?
The adaptive nature of the interface between blood and brain led some scientists to envision it more like an actively managed border crossing, not a wall.
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