9681 RESULTS
COMMENT One great drawback when studying proteins like TDP-43 is the incredible number of genes whose expression is controlled by this protein, and which become misregulated following TDP-43 aggregation in pathological conditions. From a therapeutic point of view
COMMENT Adapted from a LinkedIn post. In order to fully understand the biology of Alzheimer’s disease, to create new predictive models, and to identify novel causal and druggable targets, we need large-scale, unbiased omic analyses. For the last three years, my l
COMMENT Wang and colleagues' interesting study showed that a multidisciplinary diabetes management program in primary care settings was associated with a reduced risk of dementia incidence among patients with T2D in a cohort study in Hong Kong. Patients with
COMMENT A team of human anatomists, clinicians, and basic scientists have come together to systematically examine the controversy of intermediate leptomeningeal layer or SLYM in the brain. A preprint of the document is at this open-access link: https://osf.io/5mh
COMMENT A team of human anatomists, clinicians, and basic scientists have endeavored to examine the controversy over existence of SLYM, see open access document here https://osf.io/5mhtu/?view_only=e5a2bf6004dd498db87587ec8c32df9e drashutoshkumar_380926 0
COMMENT Might we consider that, if prions can induce Aβ seeding, microbes such as herpes simplex virus (HSV) and herpes varicella-zoster, which are transmissible, might as well? For example, studies have shown that HSV, other viruses, and many other types of orga
COMMENT Could sCJD be due to as-yet-unidentified transmission routes? Has transmission via eye procedures been excluded? 0 sumada_347611 Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients.
COMMENT In this study, we found that higher baseline levels of CSF microglial biomarkers were related to faster rates of CSF sTREM2 increase and CSF PGRN decrease. Elevated CSF p-Tau181 was associated with higher levels of CSF microglial biomarkers and faster rat
COMMENT Since the misfolded proteins have been found in eye tissues and tears—have medical procedures involving the eye been considered as possible transmission routes? sumada_347611 0
COMMENT These data are a big step forward toward effective treatment and prevention in AD. Together with results from previous clinically effective and ineffective amyloid-modulating antibodies and low molecular-weight compounds, we should now be positioned to ad
COMMENT It is remarkable that we now have several anti-amyloid therapies that have been proven to slow down the disease progression of Alzheimer’s disease when initiated in amyloid-positive patients with amnestic MCI or mild dementia. While the donanemab Phase 2
COMMENT This work is thrilling and interesting as the authors continue to report deficits of the endo-lysosomal system in aging and neurodegeneration. In both Down's and AD brains, the phosphorylated APP-β-CTF fragment selectively binds to the V0a1 subunit o
COMMENT This is an exciting study implicating the BACE1-generated APP C-terminal fragment as a key player in lysosomal dysfunction in Down’s syndrome fibroblasts and animal models. This work has a major translational implication for the use of BACE inhibitors. Th
COMMENT This study expands the extent to which lysosome dysfunction—particularly through interference of the vATPase proton pump—is implicated as an upstream pathogenic, cellular mechanism in neurological conditions such as AD and in DS, which share many proteino
COMMENT This study is elegant and intriguing. It supports a crucial role of increased phosphorylation levels of the APP Tyr682 residue in the neurons of patients with AD and DS. The study provides a mechanism through which this increased phosphorylation leads to
