Hall S, Öhrfelt A, Constantinescu R, Andreasson U, Surova Y, Bostrom F, Nilsson C, Håkan W, Decraemer H, Någga K, Minthon L, Londos E, Vanmechelen E, Holmberg B, Zetterberg H, Blennow K, Hansson O. Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders. Arch Neurol. 2012 Nov;69(11):1445-52. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(48)		 385 ± 97
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 McKhann et al., 1984
Aβ42
(CSF)		 CBS
(12)		 585 ± 139
ng/mL §		 xMAP;
Other/Not Specified;
In-house
Aβ42
(CSF)		 CTRL-
CNC
(107)		 616 ± 157
ng/mL §		 xMAP;
Other/Not Specified;
In-house
Aβ42
(CSF)		 DLB
(70)		 485 ± 147
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 McKeith et al., 2005
Aβ42
(CSF)		 MSA
(48)		 605 ± 126
ng/mL §		 xMAP;
Other/Not Specified;
In-house
Aβ42
(CSF)		 PD
(90)		 614 ± 124
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 Gelb et al., 1999
Aβ42
(CSF)		 PDD
(33)		 562 ± 158
ng/mL §		 xMAP;
Other/Not Specified;
In-house
Aβ42
(CSF)		 PSP
(45)		 576 ± 145
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 Litvan et al., 1996
NFL
(CSF)		 AD
(48)		 2569 ± 1814
ng/mL §		 ELISA;
Other/Not Specified;
UmanDiagnostics AB		 McKhann et al., 1984
NFL
(CSF)		 CBS
(12)		 4298 ± 2001
ng/mL §		 ELISA;
Other/Not Specified;
UmanDiagnostics AB
NFL
(CSF)		 CTRL-
CNC
(107)		 1140 ± 1210
ng/mL §		 ELISA;
Other/Not Specified;
UmanDiagnostics AB
NFL
(CSF)		 DLB
(70)		 2255 ± 1987
ng/mL §		 ELISA;
Other/Not Specified;
UmanDiagnostics AB		 McKeith et al., 2005
NFL
(CSF)		 MSA
(48)		 4753 ± 3065
ng/mL §		 ELISA;
Other/Not Specified;
UmanDiagnostics AB
NFL
(CSF)		 PD
(90)		 1159 ± 874
ng/mL §		 ELISA;
Other/Not Specified;
UmanDiagnostics AB		 Gelb et al., 1999
NFL
(CSF)		 PDD
(33)		 1681 ± 955
ng/mL §		 ELISA;
Other/Not Specified;
UmanDiagnostics AB
NFL
(CSF)		 PSP
(45)		 3326 ± 1365
ng/mL §		 ELISA;
Other/Not Specified;
UmanDiagnostics AB		 Litvan et al., 1996
tau-p181
(CSF)		 AD
(48)		 100 ± 37
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 McKhann et al., 1984
tau-p181
(CSF)		 CBS
(12)		 49 ± 8
ng/mL §		 xMAP;
Other/Not Specified;
In-house
tau-p181
(CSF)		 CTRL-
CNC
(107)		 54 ± 15
ng/mL §		 xMAP;
Other/Not Specified;
In-house
tau-p181
(CSF)		 DLB
(70)		 60 ± 20
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 McKeith et al., 2005
tau-p181
(CSF)		 MSA
(48)		 44 ± 4
ng/mL §		 xMAP;
Other/Not Specified;
In-house
tau-p181
(CSF)		 PD
(90)		 48 ± 6
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 Gelb et al., 1999
tau-p181
(CSF)		 PDD
(33)		 52 ± 8
ng/mL §		 xMAP;
Other/Not Specified;
In-house
tau-p181
(CSF)		 PSP
(45)		 48 ± 11
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 Litvan et al., 1996
tau-total
(CSF)		 AD
(48)		 944 ± 502
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 McKhann et al., 1984
tau-total
(CSF)		 CBS
(12)		 767 ± 523
ng/mL §		 xMAP;
Other/Not Specified;
In-house
tau-total
(CSF)		 CTRL-
CNC
(107)		 569 ± 356
ng/mL §		 xMAP;
Other/Not Specified;
In-house
tau-total
(CSF)		 DLB
(70)		 466 ± 248
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 McKeith et al., 2005
tau-total
(CSF)		 MSA
(48)		 577 ± 356
ng/mL §		 xMAP;
Other/Not Specified;
In-house
tau-total
(CSF)		 PD
(90)		 451 ± 281
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 Gelb et al., 1999
tau-total
(CSF)		 PDD
(33)		 395 ± 141
ng/mL §		 xMAP;
Other/Not Specified;
In-house
tau-total
(CSF)		 PSP
(45)		 522 ± 400
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 Litvan et al., 1996
α-synuclein
(CSF)		 AD
(48)		 101 ± 37
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 McKhann et al., 1984
α-synuclein
(CSF)		 CBS
(12)		 70 ± 31
ng/mL §		 xMAP;
Other/Not Specified;
In-house
α-synuclein
(CSF)		 CTRL-
CNC
(107)		 68 ± 25
ng/mL §		 xMAP;
Other/Not Specified;
In-house
α-synuclein
(CSF)		 DLB
(70)		 61 ± 22
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 McKeith et al., 2005
α-synuclein
(CSF)		 MSA
(48)		 58 ± 24
ng/mL §		 xMAP;
Other/Not Specified;
In-house
α-synuclein
(CSF)		 PD
(90)		 57 ± 22
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 Gelb et al., 1999
α-synuclein
(CSF)		 PDD
(33)		 62 ± 23
ng/mL §		 xMAP;
Other/Not Specified;
In-house
α-synuclein
(CSF)		 PSP
(45)		 71 ± 25
ng/mL §		 xMAP;
Other/Not Specified;
In-house		 Litvan et al., 1996

§ Data supplied to Alzforum by author

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Comments

  1. This new report from Kaj Blennow and Oskar Hansson's group appears to support our own findings that soluble α-synuclein levels are increased in brains of subjects with AD (Larson et al., 2012). Whether this elevation corresponds to a "leakage of α-synuclein from degenerating neurons" or to an influx of α-synuclein in the CSF from the periphery remains to be demonstrated. We would favor an alternate hypothesis, i.e., that brain expression of α-synuclein is profoundly increased in AD, resulting in enhanced secretion of the protein into the interstitial fluid (ISF). Another key question relates to the nature of the soluble species of α-synuclein accumulating in AD, whether it is in the ISF, CSF, or neuronal cells. More work is needed to address this question at this time. Overall, this new study and ours highlight the possible involvement of soluble α-synuclein as an important modulator of AD pathophysiology.

    References:

    Larson ME, Sherman MA, Greimel S, Kuskowski M, Schneider JA, Bennett DA, Lesné SE. Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology. J Neurosci. 2012 Jul 25;32(30):10253-66. PubMed. Correction.

    View all comments by Sylvain Lesne

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AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CBS vs AD : Aβ42 (CSF)
  3. CTRL vs AD : Aβ42 (CSF)
  4. DLB vs AD : Aβ42 (CSF)
  5. MSA vs AD : Aβ42 (CSF)
  6. PDD vs AD : Aβ42 (CSF)
  7. PD vs AD : Aβ42 (CSF)
  8. PSP vs AD : Aβ42 (CSF)
  9. AD vs CTRL : NFL (CSF)
  10. CBS vs AD : NFL (CSF)
  11. CTRL vs AD : NFL (CSF)
  12. DLB vs AD : NFL (CSF)
  13. MSA vs AD : NFL (CSF)
  14. PDD vs AD : NFL (CSF)
  15. PD vs AD : NFL (CSF)
  16. PSP vs AD : NFL (CSF)
  17. AD vs CTRL : tau-p181 (CSF)
  18. CBS vs AD : tau-p181 (CSF)
  19. CTRL vs AD : tau-p181 (CSF)
  20. DLB vs AD : tau-p181 (CSF)
  21. MSA vs AD : tau-p181 (CSF)
  22. PDD vs AD : tau-p181 (CSF)
  23. PD vs AD : tau-p181 (CSF)
  24. PSP vs AD : tau-p181 (CSF)
  25. AD vs CTRL : tau-total (CSF)
  26. CBS vs AD : tau-total (CSF)
  27. CTRL vs AD : tau-total (CSF)
  28. DLB vs AD : tau-total (CSF)
  29. MSA vs AD : tau-total (CSF)
  30. PDD vs AD : tau-total (CSF)
  31. PD vs AD : tau-total (CSF)
  32. PSP vs AD : tau-total (CSF)
  33. AD vs CTRL : α-synuclein (CSF)
  34. CBS vs AD : α-synuclein (CSF)
  35. CTRL vs AD : α-synuclein (CSF)
  36. DLB vs AD : α-synuclein (CSF)
  37. MSA vs AD : α-synuclein (CSF)
  38. PDD vs AD : α-synuclein (CSF)
  39. PD vs AD : α-synuclein (CSF)
  40. PSP vs AD : α-synuclein (CSF)