9681 RESULTS
COMMENT This study is of interest as it provides new insights into the sex dependence of the impact of ApoE4 on AD pathobiology. The inclusion of human data combined with experimental validation are major strengths of the paper. The identification of a new class
COMMENT These parallel discoveries by the Lee and Ryskeldi-Falcon teams are seminal. Together, they conclusively show that two distinct proteins, ANXA11 and TDP-43, co-assemble into organized heteromeric amyloid filaments in FTLD type C and in a subset of other T
COMMENT I think this is a very interesting and exciting discovery for several reasons. The finding of a novel type of filament as a consistent feature of FTLD-TDP type C samples confirms that these cases represent a distinct entity, and validates the current path
COMMENT In the beginning, amyloid was identified by tell-tale morphologic and staining characteristics, and little was known about its constituent proteins. As analytic methods progressed, amyloids became increasingly defined by their principal polymeric proteins
COMMENT will proceed directly to our comments. In our previous work (Yin et al., 2023), we identified
COMMENT Since the development of tau PET tracers capable of detecting the 3R/4R tau pathology in Alzheimer’s disease, there have been increased efforts to find new tracers that specifically detect 4R tau in PSP and CBD. This work by Lindberg et al. from the Vasd
COMMENT Lindberg et al. provide compelling evidence for OXD-2314 as a new lead candidate for imaging non-AD tauopathies, and AD. Indeed, 3 HOXD-2314 had selective and stronger binding affinity for tau aggregates of PSP and CBD in postmortem tissue compared with o
COMMENT The development of [18F]OXD-2314 heralds a promising advance in the imaging of tauopathies, particularly the non-Alzheimer's disease (non-AD) type. This new tracer, designed through a ligand-based approach, shows high affinity and selectivity for 4R-
COMMENT Mathis, Vasdev, and colleagues provide a model protocol for designing and evaluating PET radioligands based on chemical, pharmacokinetic, and pharmacodynamic properties. The validity of this approach will soon be examined by a clinical PET study for AD an
COMMENT Admitting a conflict of interest in commenting on this research (Subhojit's office is two
COMMENT comments already posted in Alzforum. We have long maintained that there is an important role for epigenetic
COMMENT This is a beautiful study with compelling results. That the authors discovered a role for glia in protecting neurons from wake-related oxidative stress is quite unexpected and eye-opening. The next step will be to test the extent to which this mechanism a
COMMENT This is an exciting finding. It builds on work from Hugo Bellen’s lab, which showed that astrocytes can take up lipid droplets from stressed/injured neurons as a neuroprotective mechanism. This new paper provides a novel connection to sleep deprivation, w
COMMENT This exciting new paper from the Seghal lab makes an unexpected connection between reactive oxygen species (ROS), lipid metabolism, and sleep. Previous work had shown that neurons release ROS-damaged peroxidated lipids when overexcited or stressed; these
COMMENT This is a fantastic study. It addresses fundamental issues of brain bioenergetic metabolism that relate and link to several AD-relevant phenomena, including neuron-glia interplay, apolipoprotein E biology, lipid metabolism, oxidative stress, circadian rhy
