A Facial Massage May Get the CSF Flowing
Manipulation of lymph vessels in the face and neck boosts cerebrospinal fluid drainage in old mice
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Could Monocyte-Derived Microglia Cause Some Cases of Parkinsonism?
As mice age, monocyte-derived macrophages settle in their nigrostriatal region and become bona fide microglia. Cells with hematopoiesis mutations can impair movement.
Circulating Monocytes Replace Microglia, Border-Associated Macrophages
Fetal liver monocytes were the only kind that developed a true microglia identity in mouse brains. A clue? Their chromatin structure at the Sall1 locus.
Replacing Rogue Microglia Treats Monogenic Brain Disease Krabbe
Transplanting healthy macrophages into a Krabbe mouse model erased the disease’s giant toxic cells, reduced pathology, and lengthened survival.
Can a Pen Powered by AI Detect Parkinson’s?
The device identified people with this disease in a small pilot study.
Can Sealing Burst Membranes Slow Alzheimer’s Disease Pathology?
In a mouse model of AD, the membrane repair protein annexin A6 reduced dystrophic neurites and tau phosphorylation.
Night-Night, Neurodegeneration: Sleep Aid Lulls Tau Pathology
In tauopathy mice, an orexin receptor antagonist keeps the brain from wasting away.
Do PERK’d Up Astrocytes Slow Amyloid Clearance?
Deleting the kinase PERK in astrocytes, or blocking it, restored glymphatic flow in the brains of AD mice, improving cognition and protein clearance.
Introducing Next-Gen AAVs, Now Equipped with Enhancers
Bespoke enhancers refine gene expression in both neural and non-neural cells of the central nervous system.
In Stress Granules, Does “Demixing” Seed TDP-43 Aggregation?
A high concentration of TDP-43 and a wave of oxidative stress drive protein phase transitions within the membraneless organelles.
Astrocytes, the Gatekeepers of Norepinephrine Signaling in the Brain
When the catecholamine binds adrenergic receptors on astrocytes, the glia release neuromodulators that tweak the strength of neuronal synapses.
No Mere Microglial Marker, TMEM119 Supports Aβ Phagocytosis
The transmembrane protein forms a complex with Aβ, which is then degraded with help from LRP1.
Does Loss of Neuronal Pentraxin 2 Start Network Dysfunction in Alzheimer’s?
In amyloidosis mice, a dearth of NPTX2 in layer 5/6 excitatory neurons quiets interneurons, dampening inhibitory signals. Adding NPTX2 restores them.
Are Artery Exosomes to Blame for Vascular Cognitive Impairment?
In mice, plaque-coated vessels shed extracellular vesicles that infiltrate the brain and exacerbate ischemic damage.
Modeling Tauopathies With Human Tissue
Donor-derived brain tissue and cells are helping scientists decipher the molecular pathology of human tauopathies.
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